Overview of the expertise pooled in the Fraunhofer CIMD

Biomarker analysis and development

  • Biobank
  • Biopsies (synovia, pleura, liquid biopsy)
  • Cell isolation
  • Proteome, metabolome, and lipidome analyses
  • Epigenetics
  • Sequencing
  • Next-generation cytometry
  • Biosensors
  • Single-cell diagnostics
  • Omics platforms
  • LC-MS/MS analyses 

Lead discovery

  • Cryo-electron microscopy
  • Multi-epitope ligand cartography
  • Next-generation cytometry
  • Mass spectrometry
  • Cell-based assays
  • High-throughput screening
  • Drug design
  • Medicinal chemistry 


Treatment concept

  • Development planning and target product
  • Profiles of innovative concepts and products
  • Cost efficiency
  • Genetically engineered cell therapy
  • Therapeutic antibodies
  • Nucleic acid-based therapy
  • Chemically defined therapeutics
  • Vaccination
  • Omics technologies
  • CyTOF technologies



Preclinical development

  • Cell-based human in-vitro systems (e.g. lab on a chip, 3D tissue models)
  • Human organotypic systems (e.g. ex-vivo tissue cultures)
  • Animal models (e.g. CRISPR/Cas9-based)
  • Zebra fish models
  • Insect models
  • Imaging techniques
  • Bioanalytics
  • GLP testing (safety pharmacology, toxicology) 

GMP manufacturing

  • Process development and GMP-compliant manufacturing (e.g. biopharmaceuticals, cell and gene therapeutics, candidate drugs, master and working cell banks)
  • Formulation, sterile fill and finish
  • Low-energy electron irradiation
  • Quality assurance 

Performance of phase-I and phase-II trials

  • Clinical research center
  • Acting as a sponsor
  • Phase-I units
  • Proof-of-concept studies, phase-I/phase-II trials, phase IV trials
  • Patient and volunteer database
  • Clinical project management
  • Clinical pharmacology
  • Regulatory Affairs
  • Pharmacovigilance
  • Biostatistic
  • Data management


Marketing authorization

  • Regulatory expertise from the preclinical stage to market entry
  • Health technology assessment and AMNOG processes

Early Diagnosis and Individualized Treatment of Immune Diseases

In our leaflet you will get an insight into the work of the Fraunhofer CIMD: We present the indication field of immune diseases, our bundled expertise, the path from the medical need to the new medications and our biobanks.

From medical need to novel medication

© Fraunhofer CIMD

Development of a new drug must follow a multi-tiered process prescribed by legislation. It takes more than 13 years on average from the idea to the first market approval. The majority of this time is spent on studies to test the drug’s efficacy and tolerability and to determine the most appropriate administration protocol.

Biobanks: high-quality biomaterials

© Fraunhofer IME

High-quality biomaterials are essential for conclusive, unbiased medical research findings. In the context of immune-mediated diseases, collection of such materials is often a limiting factor. The biobanks of Fraunhofer IME, Fraunhofer IZI, and Fraunhofer ITEM store, for example, blood, tissue, stool, and urine samples. These biomaterials can be used for research purposes whenever required.

We have access to the following biomaterials from patients via our institutes’ biobanks:


  • Ataxia teleangiectasia
  • Asthma (LPS challenge)
  • Asthma (rhinovirus challenge)
  • COPD GOLD 1-4
  • Eosinophilic fasciitis
  • Lupus erythematosus
  • Granulomatosis with polyangiitis
  • Psoriatic arthritis
  • Psoriasis vulgaris
  • Rheumatoid arthritis
  • Rhinitis
  • Sarkoidosis
  • Spondyloarthritiden
  • Systemic sclerosis


  • Bronchoalveolar lavage
  • Citrate plasma
  • DNA, RNA
  • EDTA whole blood
  • Skin biopsies
  • Heparin plasma
  • Lung biopsies
  • Nasopharyngeal lavage
  • PAXgene
  • PBMCs
  • Serum
  • Stem cells
  • Sputum
  • Stool, urine
  • Synovial fluid and synovia (tissue)
  • Cells from BAL (bronchoalveolar lavage), NAL (nasal lavage), and sputum
  • Cell culture supernatant