Immune diseases include a variety of diseases such as inflammatory rheumatic diseases, inflammatory skin and intestinal diseases, but also respiratory diseases, which have a significant pathophysiological similarity in the misregulation of the immune system. Although it is estimated that eight percent of the world's population is affected, it has not yet been possible to develop causal therapy principles to the point of application. Rather, only symptom-relieving drugs are currently offered. One reason for this is the variety of clinical symptoms and manifestations of these diseases, as well as the ability of the immune system to adapt to changes. The targeted development of innovative methods for the prevention, diagnosis and therapy of immune diseases therefore requires interdisciplinary networking far beyond biomedicine (“4D”).